Multiple Myeloma Research Review, Issue 34

In this issue:

De-escalation of front-line Rd beneficial for elderly, intermediate-fit patients
Outcomes after delayed and second ASCT at relapse
MRD status is prognostic for outcome in transplant-eligible patients
MANHATTAN reports high MRD-negativity rates from upfront daratumumab-based quartet
Soluble BCMA levels predict progression to MM in MGUS and SMM
IKEMA: addition of Isatuximab to carfilzomib and dexamethasone extends PFS in RR
Adherence to oral antimyeloma therapy
OPTIMISMM: PFS benefit with addition of second-line pomalidomide in RR disease
APOLLO: daratumumab extends PFS when added to pomalidomide/dexamethasone in RRMM
Direct P70S6K1 inhibition can replace dexamethasone in synergistic combination with MCL-1 inhibition

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